A Wireless Patch for the Monitoring of C-reactive Protein in Sweat
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작성자 Marla 작성일25-09-20 14:41 조회10회 댓글0건본문
The quantification of protein biomarkers in blood at picomolar-level sensitivity requires labour-intensive incubation and washing steps. Sensing proteins in sweat, BloodVitals SPO2 which might enable for point-of-care monitoring, is hindered by the sometimes giant interpersonal and intrapersonal variations in its composition. Here we report the design and efficiency of a wearable and wireless patch for the actual-time electrochemical detection of the inflammatory biomarker C-reactive (CRP) protein in sweat. The machine integrates iontophoretic sweat extraction, microfluidic channels for sweat sampling and for reagent routing and replacement, and a graphene-based sensor array for quantifying CRP (through an electrode functionalized with anti-CRP capture antibodies-conjugated gold nanoparticles), ionic strength, pH and temperature for the true-time calibration of the CRP sensor. In patients with chronic obstructive pulmonary illness, with energetic or previous infections or who had heart failure, the elevated concentrations of CRP measured via the patch correlated properly with the protein’s ranges in serum. Wearable biosensors for the true-time sensitive analysis of inflammatory proteins in sweat may facilitate the administration of chronic diseases.
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